Dipeptidyl-peptidase-like protein 6 encephalitis treated with immunotherapy
نویسندگان
چکیده
منابع مشابه
Encephalitis and antibodies to dipeptidyl-peptidase-like protein-6, a subunit of Kv4.2 potassium channels.
OBJECTIVE To report a novel cell surface autoantigen of encephalitis that is a critical regulatory subunit of the Kv4.2 potassium channels. METHODS Four patients with encephalitis of unclear etiology and antibodies with a similar pattern of neuropil brain immunostaining were selected for autoantigen characterization. Techniques included immunoprecipitation, mass spectrometry, cell-base experi...
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In cerebellar granule (CG) cells and many other neurons, A-type potassium currents play an important role in regulating neuronal excitability, firing patterns, and activity-dependent plasticity. Protein biochemistry has identified dipeptidyl peptidase-like protein 6 (DPP6) as an auxiliary subunit of Kv4-based A-type channels and thus a potentially important regulator of neuronal excitability. I...
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ژورنال
عنوان ژورنال: Baylor University Medical Center Proceedings
سال: 2020
ISSN: 0899-8280,1525-3252
DOI: 10.1080/08998280.2020.1822132